Friday 14 October 09:00~11:00 | Place: Convention hall C Chairs: Sung Woo Park, Min ho Shong
The critical role of mTOR signaling in regulating metabolic stress has received intensive attention. In this session, new understandings of mTOR signaling in major insulin-sensitive tissues with a particular emphasis on its pathophysiologic relevance will be reviewed. Professor Yoon MS (Gachon Univ. Korea) will open the session by reviewing mTOR pathways to guide the audience. Professor Chen (UIUC, IL) will address multiple signaling pathways sensing amino acids upstream of mTOR for the regulation of myogenesis. Dr. Pajvani (Columbia University, NY) will show new data on the role of mTORC1-independent free Raptor on hepatic Akt activity and lipogenesis. Professor Han JW (Sungkyunkwan Univ. Korea) will present that S6K1 suppress Wnt gene expression and drive adipogenesis via epigenetic regulatory mechanisms after adipogenic stimulation.
Mee Sup YoonGachon University, Korea
S3-1Overview of mTOR signaling
Jie ChenUniversity of Illinois, USA
S3-2mTOR signaling network in skeletal myogenesis
Utpal B. PajvaniColumbia University, USA
S3-3PHLPPs - necessary negative regulators of hepatic insulin signaling
Jeung-Whan HanSungkyunkwan University, Korea
S3-4Control of adipogenesis by S6K1-mediated epigenetic modifications
Friday 14 October 09:00~11:00 | Place: Emerald Hall B Chairs: Sung-Hee Ihm , Ki-Ho Song
A decrease in the functional beta cell mass is the key feature of both type 1 and type 2 diabetes. Thus, recovery of functional beta cell mass is thought to be a possible therapeutic strategy to cure diabetes. Recently, technology to induce beta cell differentiation from stem cells is rapidly developing and will be the new source of beta cells for transplantation. In this session, four outstanding speakers will share their recent progress on beta cell differentiation from stem cells.
Metthias HebrokUniversity of California San Francisco, USA
S5-1Maturation of human embryonic stem cell derived beta cells
Ji Won KimThe Catholic University of Korea, Korea
S5-2Differentiation of human induced pluripotent stem cells into insulin-producing cells
Timothy KiefferUniversity of British Columbia, Canada
S5-3Making mature human islet cells from stem cells to model disease and treat diabetes
Yong-Mahn HanKAIST, Korea
S5-4Glucose responsiveness of islet-like organoids generated from human pluripotent stem cells